21c Museum Hotels ​reimagines a historic St. Louis fixture: the 10-story, Renaissance Revival-style YMCA building. The 96-year-old building honors its historic roots while offering contemporary art-filled spaces, community-focused cultural programming, locally-sourced food and beverage options, and, of course, world-leading hospitality.

21c St. Louis features beautifully appointed guest rooms, including luxury suites with double-height living spaces complete with a fireplace, in-room fitness studio lofts, and upgraded amenities. 21c St. Louis also debuts a full-service athletic and swim club.

• Complimentary WiFi
• Key Secured Guest Floor
• Private Entrance Options
• Indoor Pool, Hot Tub, Spa and Fitness Center
• 173 Guest Rooms
• 21c Suite with Fitness Loft
• Library Suite with Fireplace
• 18 suites
• 115 Kings
• 33 Double Queens