Opening Early 2023. Now Booking for Stays Starting June 21, 2023.

For its tenth location, 21c Museum Hotels reimagines a historic St. Louis fixture: the 10-story, Renaissance Revival-style YMCA building. The 96-year-old building honors its historic roots, while offering contemporary art-filled spaces, community-focused cultural programming, locally-sourced food and beverage options and, of course, world-leading hospitality. 21c St. Louis features guest rooms, including luxury suites with double height living spaces complete with fireplace, in-room fitness studio lofts, and upgraded amenities. 21c St. Louis also debuts a full service wellness center. This new swim and athletic club offers fitness and movement spaces, a lap pool, hot tub, sauna, steam room, and spa treatment rooms, among other amenities to serve our guests and the community.