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The first museum hotel

Nestled in downtown Louisville on historic West Main Street, along Museum Row, 21c Museum Hotel is a multi-venue contemporary art museum, an award-winning 91-room boutique hotel, and home to acclaimed Proof on Main restaurant. Stay with us and the iconic Red Penguin

For the most up to date information about all of our cleanliness and wellness policies, designed with the safety of our teammates and guests in mind, click here.